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Molecular Biology and Bioinformatics Glossary

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C

Cancer

Diseases in which abnormal cells divide and grow unchecked. Cancer can spread from its original site to other parts of the body and can be fatal.
See also: hereditary cancer, sporadic cancer (ORNL)

Candidate gene

A gene located in a chromosome region suspected of being involved in a disease.
See also: positional cloning, protein (ORNL)

Capillary array

Gel-filled silica capillaries used to separate fragments for DNA sequencing. The small diameter of the capillaries permit the application of higher electric fields, providing high speed, high throughput separations that are significantly faster than traditional slab gels. (ORNL)

Carcinogen

Something which causes cancer to occur by causing changes in a cell's DNA.
See also: mutagen (ORNL)

Carrier

An individual who possesses an unexpressed, recessive trait. (ORNL)

cDNA library

A collection of DNA sequences that code for genes. The sequences are generated in the laboratory from mRNA sequences.
See also: messenger RNA (ORNL)

Cell

The basic unit of any living organism that carries on the biochemical processes of life.
See also: genome, nucleus (ORNL)

Centimorgan (cM)

A unit of measure of recombination frequency. One centimorgan is equal to a 1% chance that a marker at one genetic locus will be separated from a marker at a second locus due to crossing over in a single generation. In human beings, one centimorgan is equivalent, on average, to one million base pairs.
See also: megabase (ORNL)

Centromere

A specialized chromosome region to which spindle fibers attach during cell division. (ORNL)

Chimera (pl. chimaera)

An organism that contains cells or tissues with a different genotype. These can be mutated cells of the host organism or cells from a different organism or species. (ORNL)

Chloroplast chromosome

Circular DNA found in the photosynthesizing organelle (chloroplast) of plants instead of the cell nucleus where most genetic material is located. (ORNL)

Chromosomal deletion

The loss of part of a chromosome's DNA. (ORNL)

Chromosomal inversion

Chromosome segments that have been turned 180 degrees. The gene sequence for the segment is reversed with respect to the rest of the chromosome. (ORNL)

Chromosome

The self-replicating genetic structure of cells containing the cellular DNA that bears in its nucleotide sequence the linear array of genes. In prokaryotes, chromosomal DNA is circular, and the entire genome is carried on one chromosome. Eukaryotic genomes consist of a number of chromosomes whose DNA is associated with different kinds of proteins. (ORNL)

Chromosome painting

Attachment of certain fluorescent dyes to targeted parts of the chromosome. Used as a diagnositic for particular diseases, e.g. types of leukemia. (ORNL)

Chromosome region p

A designation for the short arm of a chromosome. (ORNL)

Chromosome region q

A designation for the long arm of a chromosome. (ORNL)

Clone

An exact copy made of biological material such as a DNA segment (e.g., a gene or other region), a whole cell, or a complete organism. (ORNL)

Clone bank

See: genomic library (ORNL)

Cloning

Using specialized DNA technology to produce multiple, exact copies of a single gene or other segment of DNA to obtain enough material for further study. This process, used by researchers in the Human Genome Project, is referred to as cloning DNA. The resulting cloned (copied) collections of DNA molecules are called clone libraries. A second type of cloning exploits the natural process of cell division to make many copies of an entire cell. The genetic makeup of these cloned cells, called a cell line, is identical to the original cell. A third type of cloning produces complete, genetically identical animals such as the famous Scottish sheep, Dolly.
See also: cloning vector (ORNL)

Cloning vector

DNA molecule originating from a virus, a plasmid, or the cell of a higher organism into which another DNA fragment of appropriate size can be integrated without loss of the vector's capacity for self-replication; vectors introduce foreign DNA into host cells, where the DNA can be reproduced in large quantities. Examples are plasmids, cosmids, and yeast artificial chromosomes; vectors are often recombinant molecules containing DNA sequences from several sources. (ORNL)

Closed, Partly Opened and Opened

For all-alpha structures describes the extent in which the hydrophobic core is screened by the comprising alpha-helices. Opened means that there is space for at least one more helix to be easily attached to the core (SCOP)

Code

See: genetic code (ORNL)

Codominance

Situation in which two different alleles for a genetic trait are both expressed.
See also: autosomal dominant, recessive gene (ORNL)

Codon

See: genetic code (ORNL)

Coisogenic or congenic

Nearly identical strains of an organism; they vary at only a single locus. (ORNL)

Comparative genomics

The study of human genetics by comparisons with model organisms such as mice, the fruit fly, and the bacterium E. coli. (ORNL)

Complementary DNA (cDNA)

DNA that is synthesized in the laboratory from a messenger RNA template. (ORNL)

Complementary sequence

Nucleic acid base sequence that can form a double-stranded structure with another DNA fragment by following base-pairing rules (A pairs with T and C with G). The complementary sequence to GTAC for example, is CATG. (ORNL)

Complex trait

Trait that has a genetic component that does not follow strict Mendelian inheritance. May involve the interaction of two or more genes or gene-environment interactions.
See also: Mendelian inheritance, additive genetic effects (ORNL)

Computational biology

See: bioinformatics (ORNL)

Confidentiality

In genetics, the expectation that genetic material and the information gained from testing that material will not be available without the donor's consent. (ORNL)

Congenital

Any trait present at birth, whether the result of a genetic or nongenetic factor.
See also: birth defect (ORNL)

Conservation

Changes at a specific position of an amino acid or (less commonly, DNA) sequence that preserve the physico-chemical properties of the original residue. (NCBI)

Conserved sequence

A base sequence in a DNA molecule (or an amino acid sequence in a protein) that has remained essentially unchanged throughout evolution. (ORNL)

Contig

Group of cloned (copied) pieces of DNA representing overlapping regions of a particular chromosome. (ORNL)

Contig map

A map depicting the relative order of a linked library of overlapping clones representing a complete chromosomal segment. (ORNL)

Cosmid

Artificially constructed cloning vector containing the cos gene of phage lambda. Cosmids can be packaged in lambda phage particles for infection into E. coli; this permits cloning of larger DNA fragments (up to 45kb) than can be introduced into bacterial hosts in plasmid vectors. (ORNL)

Crossover

connection links secondary structures at the opposite ends of the structural core and goes across the surface of the domain. (SCOP)

Crossing over

The breaking during meiosis of one maternal and one paternal chromosome, the exchange of corresponding sections of DNA, and the rejoining of the chromosomes. This process can result in an exchange of alleles between chromosomes.
See also: recombination (ORNL)

Cytogenetics

The study of the physical appearance of chromosomes.
See also: karyotype (ORNL)

Cytological band

An area of the chromosome that stains differently from areas around it.
See also: cytological map (ORNL)

Cytological map

A type of chromosome map whereby genes are located on the basis of cytological findings obtained with the aid of chromosome mutations. (ORNL)

Cytoplasmic (uniparental) inheritance

See: cytoplasmic trait (ORNL)

Cytoplasmic trait

A genetic characteristic in which the genes are found outside the nucleus, in chloroplasts or mitochondria. Results in offspring inheriting genetic material from only one parent. (ORNL)

Cytosine (C)

A nitrogenous base, one member of the base pair GC (guanine and cytosine) in DNA.
See also: base pair, nucleotide (ORNL)

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